Wednesday 10 January 2024

Hematologist's monologue: TO CLOT, OR NOT TO CLOT

SATIRE COMPOSED: Giorgio Coniglio (registered pseudonym) and Dr. GH, July 2019. Thoughts about blood-clotting disorders and their treatment have been incited by current health issues affecting family and friends. 
Many of today's verses are also under review at, an online humor dictionary that has accumulated over 100,000 carefully edited limericks.  Links to other medically-related posts here at "Edifying Nonsense" are given at the bottom of this post.


Coagulation disorders (executive summary)
The coagulation cascade
Deep vein thrombosis (Virchow's triad)
Pulmonary embolism


Authors' Note: The most common complication of internal bleeding in hemophilic patients is hemarthrosis, bleeding into joints, that may be unprovoked, yet result in significant disability.
Earlier versions of replacement therapy to provide for missing blood proteins with human blood-bank products has been discussed previously. Current treatment involves a genetically engineered  material derived from hamster cells, superior in not provoking antibodies that limit its effectiveness.  

Learn more about hemophilia and its current treatment with hamster-derived biosynthetic proteins at Wikipedia.

Authors' Note:

stasis: an absence of flow, or markedly reduced flow

deep venous thrombosis (DVT): a condition in which clots form in the deep veins, usually of the calves; the disorder often produces symptoms, but may be silent

The above verse conjures studies of factors in causation of DVT more than a century ago by Rudolf Virchow (FEER-koh), the famed German pathologist, that eventually resulted in the concept 'Virchow's triad'. The modern triad includes the elements of venous stasis, increased coagulability of the blood, and damage to the local endothelium (lining of the blood vessels).



Here's a LIST OF LINKS to collections of intriguing poems (over 160 of these!) on medical/dental topics that can now be found on various posts. 

If you want to resume daily titillations on our blog 'Daily Illustrated Nonsense', click HERE. Once you arrive, you can select your time frame of interest from the calendar-based listings in the righthand margin, and check the daily offerings for any month in the years 2020 through 2022. (There are now over 1200 daily entries on the Daily blog, and most of these are also presented here on 'Edifying Nonsense' in topic-based collections.)

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