Nov 15 (2023): ORGANIC BRAIN POETRY, follow-up blows [5]

 

CURRENT CONTENTS: (#2 -- November 15, 2023)

Frontal meningioma

High-dose steroids

Hyperthyroid mania

Hypothyroid depression

Metabolic delirium (3 stanzas, a 'brief saga')

Authors' Note: stroma: connective tissue that supports normal body structures and, on occasion, abnormal growths

Meningioma is a relatively common, slowly growing benign tumor within the cranium. Pressure on adjacent portions of normal brain induce neurological symptoms. When the tumor is located in the frontal cortex, neuropsychiatric manifestations may include bizarre thoughts, frequently paranoid, and unrepressed behavior. Fortunately, the tumors when suspected are readily diagnosed on neuro-imaging studies, and surgical therapy is usually curative.

Brain tumours account for only a small portion of patients suffering such neuropsychiatric symptoms; however, medical practitioners frequently hope that such a correctable cause may be discovered.

Authors' Note: A course of high-dose synthetic adrenal corticosteroids, e.g. dexamethasone, may be used to help bring under control a severe exacerbation of a chronic illness, e.g. asthma, inflammatory diseases, or an initial presentation, e.g. anaphylaxis, septic shock or brain swelling. Owing to the common side-effect of drug-induced euphoria/mania and other psychiatric issues, doctors attempt to taper the high doses as soon as possible.

Authors' Note: 

TSH: thyroid stimulating hormone, also known as thyrotropin, initialism for a substance produced by the anterior pituitary gland in a feedback loop that regulates production of thyroid hormones by the thyroid gland

The operation of the feedback loop in relation to states of thyroid deficiency is discussed HERE.

Authors' Note: 

rarefactive: (a non-standard use) — the condition of becoming less frequent; under-functioning

By far the most common cause of thyroid hormone deficiency or hypothyroidism (historically known as myxedema for a type of puffy swelling and rash in the legs) is progressive destruction of normal hormone-producing tissue by the process of colloid degeneration. Owing to the metabolic role of thyroid hormone, most body functions then slow, resulting, for example, in reduced heart rate and weight gain. For the brain, somnolence and depression may be accompanied in extreme cases by disordered mentation known as 'myxedema madness'.

Under normal circumstances, the anterior pituitary gland, stimulated by the brain's hypophysis, plays a key role as the 'master gland' in regulating hormone production. When the thyroid gland is flagging, the master gland increases its production of TSH (thyroid stimulating hormone), a messenger that is excreted into the bloodstream, targeted to normalize the peripheral gland's production. Fortunately, the robust sensing mechanism in the hypophysis and pituitary, not impaired by the metabolic slowdown elsewhere, produces high levels of blood TSH so reliably that a simple test can be used as the best test for detection of the hypothyroid state. 

Note that the three stanzas of this "brief saga" can be found in more readily legible format on the blog "Daily Illustrated Nonsense"; click HERE.

And as a later development, we put words to music. You can now sing along with the song "METABOLIC DELIRIUM" by proceeding to our blog Silly Songs and Satire". Click HERE.